The study analyzed urine samples from 314 infants less than 29 weeks gestation.
The study concluded that Paracetamol or acetaminophen metabolites (APAP) It was revealed uniformly in the urine of the majority of premature infants studied. With two diseases: bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP). In both groups of premature infants, levels were determined It was not associated with an increased risk of either adverse clinical outcome..
Research published on medRxiv confirms this. The main metabolite detected was 4-APAP sulfate.the longest and most abundant of the eight identified, Present in 98% of urine samples.
In the study, urine samples from 314 infants less than 29 weeks of gestationThe authors conducted a meta-analysis to examine the associations between APAP metabolite levels and clinical outcomes.
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Regarding the relationship between the Office of Development Policy and the Royal Oman Police, No significant relationship found. between levels of APAP metabolites and the incidence of the two diseases analyzed. Thus, these results suggest that “exposure to APAP at the doses to which the infants were exposed in these studies Does not increase the risk of BDP or ROP during the neonatal period.“
On the other hand, in exposure patterns, elevated ranges of 4-APAP sulfate levels were observed, particularly higher and for longer periods in infants fed enterally compared to those receiving total parenteral nutrition (TPN). This analysis suggests that intermittent exposure to APAP in breast milk May contribute to levels detected in children’s urine..
Although the toxic effects of APAP at high doses are known, research findings suggest that at the doses experienced by infants in these groups, APAP does not increase the risk of BDP or ROP.However, the authors emphasize the need to confirm these results, and furthermore, Does not address potential risks associated with prolonged exposure. At higher doses in premature infants.
Finally, with a view to future studies, the authors recommend that Additional investigations Your monitor measures APAP levels in both breast milk and infant formula to provide Final conclusion on the safety of APAP in this population.
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